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Soursop Nutrition

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Heavenly Heart Shaped

6-Second Ritual Defeats Deadly

Fat Inflammation and Diseases

(At the Cellular Level)

Scientific References:

  1. Mutakin, M., Fauziati, R., Fadhilah, F. N., Zuhrotun, A., Amalia, R., & Hadisaputri, Y. E. (2022, February 10). Pharmacological Activities of Soursop (Annona muricata Lin.). Molecules/Molecules Online/Molecules Annual. https://doi.org/10.3390/molecules27041201
  2. Gavamukulya, Y., Wamunyokoli, F., & El-Shemy, H. A. (2017, September 1). Annona muricata : Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pacific Journal of Tropical Medicine. https://doi.org/10.1016/j.apjtm.2017.08.009
  3. Ssenyange, C., Namulindwa, A., Oyik, B., & Ssebuliba, J. (2015, May 28). Plants used to manage type II diabetes mellitus in selected districts of central Uganda. African Health Sciences. https://doi.org/10.4314/ahs.v15i2.24
  4. De Sousa, O. V., Vieira, G. D. V., De Jesus R G De Pinho, J., Yamamoto, C. H., & Alves, M. S. (2010, May 6). Antinociceptive and Anti-Inflammatory Activities of the Ethanol Extract of Annona muricata L. Leaves in Animal Models. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms11052067
  5. Pieme, C. A., Kumar, S. G., Dongmo, M. S., Moukette, B. M., Boyoum, F. F., Ngogang, J. Y., & Saxena, A. K. (2014, December 1). Antiproliferative activity and induction of apoptosis by Annona muricata (Annonaceae) extract on human cancer cells. BMC Complementary and Alternative Medicine. https://doi.org/10.1186/1472-6882-14-516
  6. Moghadamtousi, S. Z., Kadir, H. A., Paydar, M., Rouhollahi, E., & Karimian, H. (2014, August 15). Annona muricata leaves induced apoptosis in A549 cells through mitochondrial-mediated pathway and involvement of NF-κB. BMC Complementary and Alternative Medicine. https://doi.org/10.1186/1472-6882-14-299
  7. Abdullah, M., Syam, A. F., Meilany, S., Laksono, B., Prabu, O. G., Bekti, H. S., Indrawati, L., & Makmun, D. (2017, January 1). The Value of Caspase-3 after the Application of Annona muricata Leaf Extract in COLO-205 Colorectal Cancer Cell Line. Gastroenterology Research and Practice. https://doi.org/10.1155/2017/4357165
  8. Kim, J. Y., Dao, T. T. P., Song, K., Park, S. B., Jang, H., Park, M. K., Gan, S. U., & Kim, Y. S. (2018, July 17). Annona muricataLeaf Extract Triggered Intrinsic Apoptotic Pathway to Attenuate Cancerous Features of Triple Negative Breast Cancer MDA-MB-231 Cells. Evidence-based Complementary and Alternative Medicine. https://doi.org/10.1155/2018/7972916
  9. Hadisaputri, Y. E., Habibah, U., Abdullah, F. F., Halimah, E., Mutakin, M., Megantara, S., … Diantini, A. (2021). Antiproliferation Activity and Apoptotic Mechanism of Soursop (Annona muricata L.) Leaves Extract and Fractions on MCF7 Breast Cancer Cells. Breast Cancer: Targets and Therapy, 13, 447–457. https://doi.org/10.2147/BCTT.S317682
  10. Yang, C., Gundala, S. R., Mukkavilli, R., Vangala, S., Reid, M. D., & Aneja, R. (2015, April 11). Synergistic interactions among flavonoids and acetogenins in Graviola (Annona muricata) leaves confer protection against prostate cancer. Carcinogenesis. https://doi.org/10.1093/carcin/bgv046
  11. Adewole, S., & Ojewole, J. (2010, July 27). Protective effects of <i>Annona muricata</i> linn. (Annonaceae) leaf aqueous extract on serum lipid profiles and oxidative stress in hepatocytes of streptozotocin-treated diabetic rats. African Journal of Traditional Complementary and Alternative Medicines. https://doi.org/10.4314/ajtcam.v6i1.57071
  12. Adefegha, S. A., Oyeleye, S. I., & Oboh, G. (2015, January 1). Distribution of Phenolic Contents, Antidiabetic Potentials, Antihypertensive Properties, and Antioxidative Effects of Soursop (Annona muricataL.) Fruit PartsIn Vitro. Biochemistry Research International. https://doi.org/10.1155/2015/347673
  13. De CC Pinto, N., Campos, L. M., Evangelista, A. C. S., Lemos, A. S., Silva, T. P., Melo, R. C., De Lourenço, C. C., Salvador, M. J., Apolônio, A. C. M., Scio, E., & Fabri, R. L. (2017, November 1). Antimicrobial Annona muricata L. (soursop) extract targets the cell membranes of Gram-positive and Gram-negative bacteria. Industrial Crops and Products. https://doi.org/10.1016/j.indcrop.2017.05.054
  14. Moghadamtousi, S. Z., Rouhollahi, E., Hajrezaie, M., Karimian, H., Abdulla, M. A., & Kadir, H. A. (2015, June 1). Annona muricata leaves accelerate wound healing in rats via involvement of Hsp70 and antioxidant defence. International Journal of Surgery. https://doi.org/10.1016/j.ijsu.2015.03.026
  15. Jawad M, Schoop R, Suter A, Klein P, Eccles R. Safety and Efficacy Profile of Echinacea purpurea to Prevent Common Cold Episodes: A Randomized, Double-Blind, Placebo-Controlled Trial. Evid Based Complement Alternat Med. 2012;2012:841315. doi: 10.1155/2012/841315. Epub 2012 Sep 16. PMID: 23024696; PMCID: PMC3457740.
  16. Abdelmonem, M., Kassem, S. H., Gabr, H., Shaheen, A. A., & Aboushousha, T. (2015, September 14). Avemar and Echinacea extracts enhance mobilization and homing of CD34+ stem cells in rats with acute myocardial infarction. Stem Cell Research & Therapy. https://doi.org/10.1186/s13287-015-0171-5
  17. Indrawati, L., Ascobat, P., Bela, B., Abdullah, M., & Surono, I. S. (2017). The effect of an “Annona muricata” leaf extract on nutritional status and cytotoxicity in colorectal cancer: A randomized controlled trial. Asia Pacific Journal of Clinical Nutrition, 26(4), 606–612. https://search.informit.org/doi/10.3316/informit.868704829759736
  18. Sidor, A., & Gramza-Michałowska, A. (2015, October 1). Advanced research on the antioxidant and health benefit of elderberry (Sambucus nigra) in food – a review. Journal of Functional Foods. https://doi.org/10.1016/j.jff.2014.07.012
  19. Clinic, C. (2024, May 13). 5 Ways Vitamin C Keeps You Healthy. Cleveland Clinic. https://health.clevelandclinic.org/vitamin-c
  20. Vitamin D. (2023, August 10). Mayo Clinic. https://www.mayoclinic.org/drugs-supplements-vitamin-d/art-20363792
  21. Clinic, C. (2024, May 14). How Zinc Benefits Your Body — and How Much Zinc You Need. Cleveland Clinic. https://health.clevelandclinic.org/zinc
  22. Pahwa, R., Goyal, A., & Jialal, I. (2023, August 7). Chronic Inflammation. StatPearls – NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK493173/
  23. Laurence, E. (2024, January 10). Obesity Statistics And Facts In 2024. Forbes Health. https://www.forbes.com/health/weight-loss/obesity-statistics/
  24. McCay, J. (2023, May 29). Chronically ill countries. Compare the Market. https://www.comparethemarket.com.au/life-insurance/features/chronically-ill-countries/
  25. Rd, R. R. M. (2023, March 8). Echinacea: Benefits, Uses, Side Effects, and Dosage. Healthline. https://www.healthline.com/nutrition/echinacea#side-effects
  26. Abdelmonem, M., Kassem, S. H., Gabr, H., Shaheen, A. A., & Aboushousha, T. (2015, September 14). Avemar and Echinacea extracts enhance mobilization and homing of CD34+ stem cells in rats with acute myocardial infarction. Stem Cell Research & Therapy. https://doi.org/10.1186/s13287-015-0171-5
  27. Elderberry. (2022, September 21). WebMD. https://www.webmd.com/diet/elderberry-health-benefits
  28. Barrell, A. (2023, July 25). Health benefits of elderberry. https://www.medicalnewstoday.com/articles/323288#nutrition
  29. How does health spending in the U.S. compare to other countries? – Peterson-KFF Health System Tracker. (2024, January 23). Peterson-KFF Health System Tracker. https://www.healthsystemtracker.org/chart-collection/health-spending-u-s-compare-countries/#Health%20expenditures%20per%20capita,%20U.S.%20dollars,%20PPP%20adjusted,%202022
  30. Jawad M, Schoop R, Suter A, Klein P, Eccles R. Safety and Efficacy Profile of Echinacea purpurea to Prevent Common Cold Episodes: A Randomized, Double-Blind, Placebo-Controlled Trial. Evid Based Complement Alternat Med. 2012;2012:841315. doi: 10.1155/2012/841315. Epub 2012 Sep 16. PMID: 23024696; PMCID: PMC3457740.
  31. Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev. 2010 Jul;4(8):118-26. doi: 10.4103/0973-7847.70902. PMID: 22228951; PMCID: PMC3249911.
  32. Canton, M., Sánchez-Rodríguez, R., Spera, I., Venegas, F. C., Favia, M., Viola, A., & Castegna, A. (2021, September 30). Reactive Oxygen Species in Macrophages: Sources and Targets. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2021.734229
  33. Pahwa R, Goyal A, Jialal I. Chronic Inflammation. [Updated 2023 Aug 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK493173/

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